Dr. Dian He, Assistant Professor of Chemistry and Dr. Stanley Mauldin, Associate Professor of Biology and Biochemistry, presented a poster at the 252nd American Chemical Society (ACS) National Meeting and Exposition at the Pennsylvania Convention Center on August 23. Their work was titled “Computational analysis of structure and biological function of translesion DNA polymerase zeta from Dictyostelium discoideum.”
According to their abstract, "DNA is an essential molecule that contains our genetic information that determines our physical characteristics. Being such an important molecule, DNA is fragile, and can be damaged by multiple internal and external agents. Therefore, DNA needs to be repaired, or the damage needs to be bypassed to preserve the genetic integrity. Polymerase zeta is one of the proteins can that can bypass the damaged sites on DNA. Our model organism, Dictyostelium discoideum, is an organism that is highly resistant to DNA damage and therefore mimics cancer cells that have become resistant to chemotherapy. To gain insight on the mechanism of bypassing the DNA damages, we are exploring the structure of polymerase zeta and its interaction with a damaged DNA molecule, both in lab and through computer simulation. The computer simulation results were presented during the American Chemical Society National Conference.”
The American Chemical Society strives to advance science, advocate for chemistry, enable career development, educate the public, support future chemists, and promote diversity. The ACS represents more than 140 countries, with nearly 157,000 members.
"This is my first time attending the American Chemical Society Convention and I found the presentations on DNA repair to be very enlightening,” said Dr. Mauldin. “I enjoyed interacting with other professionals in the same field."
He continued, “I’ve attended the ACS Convention many times and I appreciate the opportunity to present our research. There was a great turn out and many people showed interest in our poster."