Christopher Carbone

PhD

Assistant Professor
Education

BS, Biology, St. Joseph's University
PhD, Molecular Biology and Genetics, Temple University School of Medicine

Courses Taught

Anatomy and Physiology
Cell Biology
Genetics
Immunology
Microbiology
Molecular Biology
Topics in Scientific Laboratory Research

Teaching Focus/Philosophy

A good teacher must first captivate their audience if they wish to convey the material effectively. When teaching I hold my students to the same standards I apply to myself in that if you cannot explain a topic simply, you do not understand it well enough. The true test of a good teacher is not the number of questions I ask my students that they can answer, but how many questions I can inspire them to ask me that demonstrates they applied critical thinking skills to the subject material.

Recent Presentations/Publications

Katlinskaya YV, Carbone CJ, Yu Q, Fuchs SY. Type 1 interferons contribute to the clearance of senescent cell.Cancer Biol Ther. 2015;16(8):1214-9. doi: 10.1080/15384047.2015.1056419. Epub 2015 Jun 5.PMID: 26046815

Yu Q, Katlinskaya YV, Carbone CJ, Zhao B, Katlinski KV, Zheng H, Guha M, Li N, Chen Q, Yang T, Lengner CJ, Greenberg RA, Johnson FB, Fuchs SY. DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. Cell Rep. 2015 May 5;11(5):785-97. doi: 10.1016/j.celrep.2015.03.069. Epub 2015 Apr 23. PMID: 25921537

Yu Q, Carbone CJ, Katlinskaya YV, Zheng H, Zheng K, Luo M, Wang PJ, Greenberg RA, Fuchs SY. Type I interferon controls propagation of long interspersed element-1. J Biol Chem. 2015 Apr 17;290(16):10191-9. doi: 10.1074/jbc.M114.612374. Epub 2015 Feb 25.PMID: 25716322

Bhattacharya S, Katlinski KV, Reichert M, Takano S, Brice A, Zhao B, Yu Q, Zheng H, Carbone CJ, Katlinskaya YV, Leu NA, McCorkell KA, Srinivasan S, Girondo M, Rui H, May MJ, Avadhani NG, Rustgi AK, Fuchs SY. Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury.EMBO Mol Med. 2014 Mar;6(3):384-97. PMID: 24480543

Carbone CJ, Fuchs SY Eliminative signaling by janus kinases: role in the downregulation of associated receptors. J Cell Biochem. 2014 Jan;115(1):8-16. PMID: 23959845Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B,

Carbone CJ, Aressy B, Fuchs SY, Greenberg RA..A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep. 2013 Oct 17;5(1):180-93. PMID:24075985 Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Zhang ZY, Baker DP, Radha U, Bence KB, and Fuchs SY. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):PMID:23129613

Qian J, Zheng H, Huangfu WC, Liu J, Carbone CJ, Leu NA, Baker DP, Fuchs SY Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog. 2011 Jun;7(6) PMID: 21695243

LKumar KG, Barriere H, Carbone CJ, Liu J, Swaminathan G, Xu P, Li Y, Baker DP, Peng J, Lukacs GL, Fuchs SY. Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol. 2007 Dec 3;179(5):935-50. PMID: 18056411

p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts. Carbone CJ, Graña X, Reddy EP, Haines DS. Cancer Res. 2007 May 1;67(9):4130-7.

Christopher Carbone
Contact
Office: HFH 408E
Phone: 267-341-3256